Murray D Norris Selected Research

multidrug resistance-associated protein 1

1/2022	GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators.
10/2019	MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells.
1/2016	ABC transporters as mediators of drug resistance and contributors to cancer cell biology.
9/2014	High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).
10/2009	Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol.
8/2009	Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
4/2006	Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma.
10/2005	The role of the multidrug resistance-associated protein 1 gene in neuroblastoma biology and clinical outcome.
4/2005	Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.
1/2004	MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma.

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Murray D Norris Research Topics

Disease

72	Neoplasms (Cancer) 01/2022 - 09/2003
60	Neuroblastoma 11/2021 - 03/2003
14	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 06/2002
14	Carcinogenesis 01/2021 - 07/2003
12	Leukemia 01/2022 - 06/2002
8	Breast Neoplasms (Breast Cancer) 10/2019 - 07/2003
7	Residual Neoplasm 08/2015 - 02/2003
3	Ovarian Epithelial Carcinoma 04/2022 - 07/2014
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 11/2014
3	Brain Neoplasms (Brain Tumor) 12/2021 - 06/2015
3	Hematologic Neoplasms (Hematological Malignancy) 01/2021 - 01/2020
3	Ovarian Neoplasms (Ovarian Cancer) 10/2019 - 07/2014
2	Diffuse Intrinsic Pontine Glioma 12/2021 - 01/2021
2	Hypoxia (Hypoxemia) 01/2020 - 10/2007
2	Lung Neoplasms (Lung Cancer) 10/2019 - 04/2014
2	Neoplasm Metastasis (Metastasis) 08/2016 - 04/2014
1	Glioma (Gliomas) 12/2021
1	Rheumatoid Arthritis 01/2021
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2020
1	Multiple Myeloma 01/2020
1	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2020
1	Necrosis 01/2019
1	Lymphoma (Lymphomas) 01/2019

Drug/Important Bio-Agent (IBA)

23	Pharmaceutical PreparationsIBA 01/2022 - 07/2003
23	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2003
10	multidrug resistance-associated protein 1IBA 01/2022 - 01/2004
10	ATP-Binding Cassette Transporters (ABC Transporters)IBA 10/2019 - 01/2010
9	EnzymesIBA 04/2021 - 09/2007
9	Oncogene Proteins (Oncogene Protein)IBA 04/2021 - 02/2010
7	Histone Deacetylase InhibitorsIBA 01/2022 - 10/2007
7	PolyaminesIBA 12/2021 - 12/2008
7	Small Interfering RNA (siRNA)IBA 08/2016 - 10/2007
6	Transcription Factors (Transcription Factor)IBA 01/2021 - 02/2012
6	Adenosine Triphosphate (ATP)IBA 10/2020 - 06/2010
5	Histone Deacetylases (Histone Deacetylase)IBA 01/2022 - 11/2007
5	CBLC137IBA 01/2022 - 11/2015
5	Biological ProductsIBA 10/2020 - 06/2002
5	Vincristine (Oncovin)FDA LinkGeneric 01/2020 - 06/2002
5	Eflornithine (Ornidyl)FDA Link 01/2019 - 12/2008
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2014
4	ChromatinIBA 01/2022 - 11/2015
4	RNA (Ribonucleic Acid)IBA 11/2020 - 01/2016
4	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 10/2019 - 05/2011
4	RetinoidsIBA 08/2015 - 03/2003
4	Folic Acid (Vitamin M)FDA LinkGeneric 06/2015 - 06/2010
3	Glutathione (Reduced Glutathione)IBA 01/2022 - 01/2016
3	PanobinostatIBA 01/2022 - 01/2019
3	Drug CombinationsIBA 01/2022 - 01/2021
3	N-Myc Proto-Oncogene ProteinIBA 11/2019 - 06/2011
3	Long Noncoding RNAIBA 11/2019 - 04/2014
3	CationsIBA 01/2019 - 01/2012
3	Messenger RNA (mRNA)IBA 01/2018 - 01/2016
3	Indicators and Reagents (Reagents)IBA 01/2018 - 02/2003
2	CholesterolIBA 04/2022 - 07/2014
2	dipinacoline glutamateIBA 12/2021 - 01/2021
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 11/2021 - 06/2007
2	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 04/2021 - 01/2019
2	OT-82IBA 01/2020 - 01/2020
2	NAD (NADH)IBA 01/2020 - 01/2020
2	Carrier Proteins (Binding Protein)IBA 11/2019 - 11/2009
2	Caspase 2IBA 01/2019 - 05/2013
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2017 - 04/2005
2	Conditioned Culture MediaIBA 02/2016 - 11/2009
2	LipidsIBA 01/2015 - 07/2014
2	reversanIBA 08/2011 - 08/2009
2	Protein Glutamine gamma Glutamyltransferase 2IBA 02/2010 - 11/2007
2	Protein Isoforms (Isoforms)IBA 02/2010 - 10/2009
2	Antisense OligonucleotidesIBA 07/2009 - 09/2003
2	DNA (Deoxyribonucleic Acid)IBA 09/2007 - 07/2003
1	Membrane Transport Proteins (Biological Pump)IBA 01/2022
1	ruxolitinibIBA 11/2021
1	Quinacrine (Mepacrine)IBA 01/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2021
1	SE486-11IBA 01/2021
1	PolyubiquitinIBA 01/2021
1	Nucleosomes (Nucleosome)IBA 01/2021
1	Ubiquitin-Specific ProteasesIBA 01/2021
1	Auranofin (Ridaura)FDA Link 01/2021
1	Proteasome InhibitorsIBA 01/2021
1	RNA Helicases (RNA Helicase)IBA 01/2021
1	carfilzomibIBA 01/2021
1	OTX015IBA 01/2021
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	LuciferasesIBA 01/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	AntimetabolitesIBA 01/2020
1	Ribosomal Proteins (Ribosomal Protein)IBA 11/2019
1	Arsenic Trioxide (Trisenox)FDA Link 10/2019
1	Buthionine SulfoximineIBA 10/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	BCT-100IBA 01/2019

Therapy/Procedure

33	Therapeutics 01/2022 - 02/2003
19	Drug Therapy (Chemotherapy) 01/2022 - 02/2003
3	Immunotherapy 01/2021 - 07/2015
2	Precision Medicine 01/2022 - 11/2020
2	Radiotherapy 07/2015 - 07/2009
1	Heterologous Transplantation (Xenotransplantation) 01/2022
1	Transplantation 01/2021
1	Combined Modality Therapy 01/2021